ETIDRONIC ACID (1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID)

ETIDRONIC ACID

PRODUCT IDENTIFICATION

CAS NO.

2809-21-4

ETIDRONIC ACID

EINECS NO. 220-552-8

FORMULA C₂H₈O₇P₂

MOL WT. 206.03

H.S. CODE

TOXICITY

SYNONYMS HEDP; (Hydroxyethylidene) diphosphonic acid;

1-Hydroxyethane-1,1-diphosphonic acid; 1-Hydroxyethylidene-1,1-diphosphonic acid; 1-hydroxyethylidenedi(phosphonic acid); Dequest 2010;

CLASSIFICATION

PHOSPHONATES /

PHYSICAL AND CHEMICAL PROPERTIES (60%)

PHYSICAL STATE

clear to yellow liquid

MELTING POINT -25 C

BOILING POINT

SPECIFIC GRAVITY 1.43 - 1.46

SOLUBILITY IN WATER

miscible

AUTOIGNITION

pH < 2 (1% solution)

VAPOR DENSITY

NFPA RATINGS Health: 3; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

FLASH POINT

STABILITY Stable under ordinary conditions.

APPLICATIONS

Phosphonates derived from phosphorous (phosphonic) acid are employed in the applications of scale Inhibition, sequestration, dispersion and corrosion inhibition in addition to the main applications of agricultural chemicals such as fertilizers, pesticides, and soil conditioners. Phosphonates offer a wide range of sequestrants to control metal ions in aqueous systems. By forming stable water soluble complexes with multivalent metal ions, phosphonates prevent undesired interaction by blocking normal reactivity of metal ions. This ability contributes to function as threshold industrial water treatment and metal treatment processes (antiscalants, corrosion inhibitors, chelants, sludge conditioners, pulp bleachings, deflocculants, dispersants, metal cleaners, electroplating and crystal growth modifiers). Phosphonates are also used in manufacturing detergents, cosmetics and personal care products for special functions such as low levels iron control, stain removal, bleach stabilization, peroxide stabilization and anti-encrustation. Phosphonates existing in various compounds as acids or salts are marketed in the form of concentrated solutions.

SALES SPECIFICATION

APPEARANCE

clear to yellow liquid

ACTIVE MATTER

58.0 - 62.0%

CHLORIDE

0.3% max

IRON

10ppm max

TRANSPORTATION

PACKING 250kgs in Drum

HAZARD CLASS

UN NO.

OTHER INFORMATION

European Hazard Symbols: C, Risk Phrases: 10/35, Safety Phrases: 9/16/23/26/28A/33/36

PHARMACEUTICAL APPLICATION OF BIPHOSPHONATE

Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as osteoporosis, metastatic disease, and Paget's disease. While bisphosphonates are analogues of endogenous pyrophosphate structurally, they are characterized by a P-C-P bond, the linking oxygen is replaced with a carbon, which is resistant to enzymatic and chemical hydrolysis. General structure is

Bisphosphonate

Side chains are responsible for chemical-physicla properties, mechanism of resorption, and pharmacokinetics. It is known that biphosphonates bind strongly to hydroxyapatite crystals at the sites of increased bone turnover preferentially and inhibit the formation, aggregation, and dissolution of the crystals.They also may inhibit osteoclast function directly, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation.
Bisphosphonate products include: (see belows)

Etidronic acid (CAS #: 2809-21-4)
Clodronic acid (CAS #: 10596-23-3)
Tiludronic acid (CAS #: 89987-06-4)
Medronic acid (CAS #: 1984-15-2)
Pamidronic acid (CAS #: 40391-99-9)
Neridronic acid (CAS #: 79778-41-9)
Olpadronic acid (CAS #: 63132-39-8)
Alendronic acid (CAS #: 66376-36-1)
Ibandronic acid (CAS #: 114084-78-5)
Risedronic acid (CAS #: 105462-24-6)
Zoledronic Acid (CAS #: 118072-93-8)

Biphosphonate (Sosium salt)	CAS #	Side Chains (R1, R2)	STRUCTURE
Alendronic acid (Alendronate)	66376-36-1	R1= -OH R2= -C₃H₆NH₂
Clodronic acid (Clodronate)	10596-23-3	R1= -Cl R2= -Cl
Etidronic acid (Etidronate)	2809-21-4	R1= -OH R2= -CH₃
Ibandronic acid (Ibandronate)	114084-78-5	R1= -OH R2= -C₂H₄N(CH₃)C₅H₁₁
Medronic acid (Medronate)	1984-15-2	R1= -H R2= -H
Neridronic acid (Neridronate)	79778-41-9	R1= -OH R2= -C₅H₁₀NH₂
Olpadronic acid (Olpadronate)	63132-39-8	R1= -OH R2= -C₂H₄N(CH₃)₂
Pamidronic acid (Pamidronate)	40391-99-9	R1= -OH R2= -C₂H₄NH₂
Risedronic acid (Risedronate)	105462-24-6	R1= -OH R2=
Tiludronic acid (Tiludronate)	89987-06-4	R1= -H R2= -S-CH₄Cl
Zoledronic Acid (Zoldronate)	118072-93-8	R1= -OH R2=

PRICE INFORMATION